One such mechanism that is at the core of neuronal function is based on rapid and reversible reversal of the electrical potential difference across the plasma membrane. Thursday, July 5, 2012Neurons rely on a number of mechanisms to perform their important jobs of ( i) receiving information, ( ii) information processing, ( iii) signal propagation, and ( iv) signal transmission. The interactive graph provided in this tutorial allows for a good understanding of the Hill equation, how the reaction velocity changes as a function of the substrate concentration, and how changes in V max, K 0.5, and n alter the shape of the graph. Examination of reaction kinetics by using the Hill equation is useful because it reveals three important kinetic parameters: (1) the maximum rate of the reaction, also referred to as the maximum reaction velocity ( V max), (2) the half-maximal concentration constant ( K 0.5), which is the substrate concentration that gives rise to 50% V max, and (3) the Hill coefficient ( n), which provides a measure of substrate binding cooperativity. This equation is also commonly used to describe the rate of transporter-mediated translocation of ions and molecules across biological membranes. The Hill equation is often used to describe the rate of a reaction catalyzed by an enzyme as a function of the substrate concentration. ![]() Wednesday, October 22, 2014The Hill equation is used to describe substrate-protein interactions that exhibit a sigmoidal shape.
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